Article
Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells.
Oncogene - 1 Apr 1993
Storey A, Banks L
Abstract excerpt
Human papillomaviruses (HPVs) are small DNA tumor viruses, a subset of which is closely associated with the development of cervical cancer. The viral E6 and E7 open reading frames encode multifunctional proteins that bind respectively to the p53 protein and to the product of the retinoblastoma tu...
Topics
- Animals
- Base Sequence
- Cell Transformation, Viral
- Cells, Cultured
- Gene Expression
- Genes, ras
- In Vitro Techniques
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Oncogene Proteins, Viral
- Papillomaviridae
- Polymerase Chain Reaction
- RNA, Messenger
- Repressor Proteins
- Tumor Suppressor Protein p53