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Article

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

1 Dec 1991

Abstract excerpt

We have shown previously that introduction of the human papillomavirus type 16 (HPV16) or HPV18 genome into human mammary epithelial cells induces their immortalization. These immortalized cells have reduced growth factor requirements. We report here that transfection with a single HPV16 gene E6 is sufficient to immortalize these cells and reduce their growth factor requirements. The RB protein is normal in these...

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PMID: 1658367
DOI: 10.1128/jvi.65.12.6671-6676.1991

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Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cellsPMID 1658367Read ↗

Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cellsSemantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

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Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements.Semantic proximity Read ↗

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E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescenceSemantic proximity Read ↗

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