Article
Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.
Journal of virology - 1 Jul 1992
Sedman S A, Hubbert N L, Vass W C, Lowy D R, Schiller J T
Abstract excerpt
Human papillomavirus type 16 (HPV16) E6 and E7 are selectively retained and expressed in HPV16-associated human genital tumors. E6 is active in several cell culture assays, including transformation of NIH 3T3 cells, trans activation of the adenovirus E2 promoter, and cooperation with E7 to immortalize normal human keratinocytes. Biochemically, the HPV16 E6 protein has been shown to bind to tumor suppressor...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Transformation, Viral
- Humans
- Keratinocytes
- Mice
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Precipitin Tests