Association of human papillomavirus types 16 and 18 E6 proteins with p53.

doi:10.1126/science.2157286

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Article

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

Science (New York, N.Y.) - 6 Apr 1990

Werness B A, Levine A J, Howley P M

Abstract excerpt

Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to the retinoblastoma tumor suppressor gene product, pRB. This study shows that the E6 protein of HPV...

Topics

Adenovirus Early Proteins
Amino Acid Sequence
Antigens, Polyomavirus Transforming
Base Sequence
Cell Transformation, Neoplastic
Cell Transformation, Viral
Cloning, Molecular
DNA-Binding Proteins
Humans
Immunosorbent Techniques
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins

Oncogene Proteins, Viral

Papillomaviridae

Phosphoproteins

Polymerase Chain Reaction

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 2157286
DOI: 10.1126/science.2157286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2157286-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Association of human papillomavirus types 16 and 18 E6 proteins with p53.PMID 2157286Read ↗

Interaction of HPV E6 with p53 and associated proteins.Semantic proximity Read ↗

Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600Semantic proximity Read ↗

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other propertiesSemantic proximity Read ↗

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Semantic proximity Read ↗

Human Papillomavirus Type 16 E6 Promotes Retinoblastoma Protein Phosphorylation and Cell Cycle ProgressionSemantic proximity Read ↗

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genesSemantic proximity Read ↗

Human Papillomavirus E6 and E7: Proteins which deregulate the cell cycleSemantic proximity Read ↗

Cellular binding partners of the human papillomavirus E6 proteinSemantic proximity Read ↗

Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells.Semantic proximity Read ↗

The E6 variant proteins E6I-E6IV of human papillomavirus 16: expression in cell free systems and bacteria and study of their interaction with p53.Semantic proximity Read ↗

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription.Semantic proximity Read ↗

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.Semantic proximity Read ↗

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