Article
Conditional immortalization of primary cells by human papillomavirus type 18 E6 and EJ-ras defines an E6 activity in G0/G1 phase which can be substituted for mutations in p53.
Oncogene - 17 Aug 1995
Storey A, Massimi P, Dawson K, Banks L
Abstract excerpt
The human papillomavirus (HPV) type 18 E6 gene cooperates with activated Ha-ras to immortalize primary mouse cells in culture. Using a plasmid where HPV18 E6 expression is regulated by the glucocorticoid inducible MMTV LTR, we have generated immortalized cell lines in which the continued expressi...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Cycle
- Cell Line
- Cell Line, Transformed
- Cells, Cultured
- Cloning, Molecular
- DNA-Binding Proteins
- G1 Phase
- Genes, p53
- Genes, ras
- Glucocorticoids
- Humans
- Mammary Tumor Virus, Mouse
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data