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Article

The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNA

1 Sept 1996

Abstract excerpt

Human papillomavirus type 16 (HPV-16) is the most common papillomavirus genome found in human cervical cancers and its DNA is capable of immortalizing primary keratinocytes in vitro. When expressed by their native promoter, two separate HPV-16 oncogenes, E6 and E7, cooperate to immortalize primary human keratinocytes. Early HPV cervical lesions express abundant amounts of E5-specific RNA, and using a quantitative...

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Identifiers

PMID: 8806560
DOI: 10.1006/viro.1996.0475

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The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNAPMID 8806560Read ↗

The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18Semantic proximity Read ↗

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.Semantic proximity Read ↗

The Human Papillomavirus Type 16 E5 Gene Cooperates with the E7 Gene to Stimulate Proliferation of Primary Cells and Increases Viral Gene ExpressionSemantic proximity Read ↗

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycleSemantic proximity Read ↗

Papillomavirus E6 and E7 proteins and their cellular targetsSemantic proximity Read ↗

Molecular mechanisms of cervical carcinogenesis by high‐risk human papillomaviruses: novel functions of E6 and E7 oncoproteinsSemantic proximity Read ↗

Human papillomavirus-16 E5 protein: oncogenic role and therapeutic valueSemantic proximity Read ↗

Quantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle.Semantic proximity Read ↗

The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.Semantic proximity Read ↗

Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicitySemantic proximity Read ↗

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in cultureSemantic proximity Read ↗

The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life CycleSemantic proximity Read ↗

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