Article
Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.
Journal of virology - 1 Jan 1991
Crook T, Fisher C, Vousden K H
Abstract excerpt
The E7 protein is one of the principle transforming proteins encoded by human papillomavirus type 16 (HPV16), a virus strongly associated with the development of cervical carcinoma. In the present study we show that cotransfection of wild-type human or murine p53 sequences with E7 and ras markedl...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Culture Media
- Genes, ras
- Humans
- Kinetics
- Mice
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins
- Plasmids
- Repetitive Sequences, Nucleic Acid
- Transfection
- Tumor Suppressor Protein p53