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The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19 ARF

1 Sept 1999

Abstract excerpt

High-risk human papillomaviruses are causally associated with cervical cancer. Two viral oncogenes, E6 and E7, are expressed in most cervical cancers, and these genes cause cancer when expressed in experimental animals. The E6 protein targets the p53 tumor suppressor for degradation, while the E7 protein inactivates the retinoblastoma susceptibility protein (pRb), in part by stimulating its degradation. In...

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PMID: 10438849
DOI: 10.1128/jvi.73.9.7590-7598.1999

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The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19 ARFPMID 10438849Read ↗

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High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve OncogenesisSemantic proximity Read ↗

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Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins.Semantic proximity Read ↗

Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle CheckpointSemantic proximity Read ↗

Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.Semantic proximity Read ↗

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genesSemantic proximity Read ↗

Stabilization and Functional Impairment of the Tumor Suppressor p53 by the Human Papillomavirus Type 16 E7 OncoproteinSemantic proximity Read ↗

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription.Semantic proximity Read ↗

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