Article
Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1993
Shirasaka T, Yarchoan R, O'Brien M C, Husson R N, Anderson B D, Kojima E, Shimada T, Broder S, Mitsuya H
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) strains were isolated from nine patients before and after prolonged therapy with either an alternating regimen of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC) (AZT/ddC) or 2',3'-dideoxyinosine (ddI) alone. All strains obtained from f...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Didanosine
- Dose-Response Relationship, Drug
- Genetic Variation
- HIV-1
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Zalcitabine
- Zidovudine