Multiple-drug-resistant mutants of feline immunodeficiency virus selected with 2',3'-dideoxyinosine alone and in combination with 3'-azido-3'-deoxythymidine.

doi:10.1128/AAC.38.4.861

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Article

Multiple-drug-resistant mutants of feline immunodeficiency virus selected with 2',3'-dideoxyinosine alone and in combination with 3'-azido-3'-deoxythymidine.

Antimicrobial agents and chemotherapy - 1 Apr 1994

Gobert J M, Remington K M, Zhu Y Q, North T W

Abstract excerpt

Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in...

Topics

Animals
Antiviral Agents
Cats
Cells, Cultured
Didanosine
Drug Resistance, Microbial
Foscarnet
Immunodeficiency Virus, Feline
Mutation
Phenotype
Zalcitabine
Zidovudine

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