Article
Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias.
American journal of obstetrics and gynecology - 1 Sept 1993
Kohler M F, Nishii H, Humphrey P A, Saski H, Marks J, Bast R C, Clarke-Pearson D L, Boyd J, Berchuck A
Abstract excerpt
OBJECTIVE: Mutation and overexpression of the p53 gene occur in approximately 20% of endometrial carcinomas. To determine whether alteration of the p53 gene is an early event in endometrial carcinogenesis, we examined the p53 gene in endometrial hyperplasias. STUDY DESIGN: Genomic deoxyribonucleic acid was extracted from 117 endometrial hyperplasias (36 simple, 40 complex, 41 atypical) and 30 endometrial cancers....
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