Article
Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias.
American journal of obstetrics and gynecology - 1 Sept 1993
Kohler M F, Nishii H, Humphrey P A, Saski H, Marks J, Bast R C, Clarke-Pearson D L, Boyd J, Berchuck A
Abstract excerpt
OBJECTIVE: Mutation and overexpression of the p53 gene occur in approximately 20% of endometrial carcinomas. To determine whether alteration of the p53 gene is an early event in endometrial carcinogenesis, we examined the p53 gene in endometrial hyperplasias. STUDY DESIGN: Genomic deoxyribonuclei...
Topics
- Base Sequence
- DNA, Single-Stranded
- Endometrial Hyperplasia
- Endometrial Neoplasms
- Female
- Genes, p53
- Humans
- Molecular Conformation
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic