Article
Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma.
Folia histochemica et cytobiologica - 1 Jan 2009
Dobrzycka Bozena, Terlikowski Sławomir J, Mazurek Andrzej, Kowalczuk Oksana, Niklińska Wiesława, Chyczewski Lech, Kulikowski Marek
Abstract excerpt
The aim of this study was to examine the prevalence and clinicopathological significance of KRAS point mutation in endometrial hyperplasia and carcinoma. We analysed KRAS in 11 cases of complex atypical hyperplasia and in 49 endometrial carcinomas using polymerase chain reaction associated with restriction fragment length polymorphism (PCR-RFPL). Point mutations at codon 12 of KRAS oncogene were identified in 7...
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