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Article

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling.

Developmental cell - 1 Jun 2003

Zenz Rainer, Scheuch Harald, Martin Paul, Frank Carsten, Eferl Robert, Kenner Lukas, Sibilia Maria, Wagner Erwin F

Abstract excerpt

To investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun(Deltaep)) develop normal skin but express reduced levels of EGFR in the eyelids, leading to open eyes at birth, as observed in EGFR null mice. Primary keratinocytes from c-jun(Deltaep) mice proliferate poorly, show increased...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12791272
DOI: 10.1016/s1534-5807(03)00161-8

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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