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Article

Mutational analysis of functional domains in the HIV-1 Rev trans-regulatory protein.

Virology - 1 Aug 1991

Berger J, Aepinus C, Dobrovnik M, Fleckenstein B, Hauber J, Böhnlein E

Abstract excerpt

HIV-1 replication depends on the expression of trans-regulatory genes (tat, rev) encoded in the 3' part of the retroviral genome. HIV-1 Rev trans-activator protein allows the cytoplasmic translocation of incompletely spliced retroviral mRNA which is required for the translational switch from regulatory (Tat, Rev, Nef) to structural proteins (Gag, Pol, Env). The HIV-1 Rev regulatory protein comprises an activation...

Topics

Amino Acid Sequence
Blotting, Northern
Blotting, Western
Cell Line
Gene Products, rev
HIV-1
Humans
Molecular Sequence Data
Mutation
RNA, Viral
Trans-Activators
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

rev Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 1853565
DOI: 10.1016/0042-6822(91)90992-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1853565-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutational analysis of functional domains in the HIV-1 Rev trans-regulatory protein.PMID 1853565Read ↗

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