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Article

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Friedman P N, Kern S E, Vogelstein B, Prives C

Abstract excerpt

Murine p53 blocks many of the replication activities of simian virus 40 (SV40) large tumor antigen (T antigen) in vitro. As murine cells do not replicate SV40 DNA, it was of interest to determine how p53 from permissive human cells functions. Recombinant baculoviruses encoding either the wild-type form of human p53 or a mutant p53 cloned from a human tumor cell line were constructed, and p53 proteins were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2174557
DOI: 10.1073/pnas.87.23.9275
PMCID: PMC55147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.PMID 2174557Read ↗

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