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Article

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Friedman P N, Kern S E, Vogelstein B, Prives C

Abstract excerpt

Murine p53 blocks many of the replication activities of simian virus 40 (SV40) large tumor antigen (T antigen) in vitro. As murine cells do not replicate SV40 DNA, it was of interest to determine how p53 from permissive human cells functions. Recombinant baculoviruses encoding either the wild-typ...

Topics

Animals
Antigens, Polyomavirus Transforming
Cell Line
DNA Helicases
DNA Replication
DNA, Viral
Humans
Insect Viruses
Insecta
Kinetics
Mutation
Simian virus 40

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

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Identifiers

PMID: 2174557
DOI: 10.1073/pnas.87.23.9275
PMCID: PMC55147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2174557-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.PMID 2174557Read ↗

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Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replicationSemantic proximity Read ↗

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