[Analysis of mutations in the genome of cold-adapted strains of influenza A virus using extended modification of polymerase chain restriction method].

Abstract excerpt

Cold-adapted influenza viruses A/Leningrad/13 4/17/5 7 (H2N2) (Len/17) and A/Leningrad/I 34/4 7/57 (H2N2) (Len/47) are used in Russia to prepare live reassortant cold-adapted influenza vaccines (LIV) for adults and children, respectively. Comparison between the nucleotide sequences of the Len/17 strain and the initial wild-type strain A/Leningrad/13 4/5 7 (H2N2) revealed ten nucleotide substitutions (eight of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Physiological
• Share to Amino Acid Substitution