[The NS gene--a possible determinant of apathogenicity of a cold-adapted donor of attenuation A /Leningrad/134/47/57 and its reassortants].

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Article

[The NS gene--a possible determinant of apathogenicity of a cold-adapted donor of attenuation A /Leningrad/134/47/57 and its reassortants].

Voprosy virusologii - 1 Jan 2000

Egorov A Iu, Garmashova L M, Lukashok I V, Nevedomskaia G N, Aleksandrova G I, Klimov A I

Abstract excerpt

Phenotypical properties of single-gene reassortants of attenuated cold-adapted strain A/Leningrad/135/47/57 (H2N2) and strain A/PR8/34 virulent for laboratory animals were studied. Only the group of reassortants inheriting NS gene from cold-adapted virus was fully attenuated for various animals s...

Topics

Adaptation, Physiological
Animals
Carnivora
Cells, Cultured
Chickens
Cold Temperature
Dogs
Influenza A virus
Mice
Phenotype
Vaccines, Attenuated
Viral Nonstructural Proteins
Viral Vaccines
Virulence

Source

Open in PubMed

Identifiers

PMID: 7716901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7716901-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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