Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.

doi:10.1099/vir.0.83014-0

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Article

Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.

The Journal of general virology - 1 Oct 2007

Tsfasman T M, Markushin S G, Akopova I I, Ghendon Y Z

Abstract excerpt

A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the...

Topics

Acclimatization
Cold Temperature
Genetic Complementation Test
Genotype
Humans
Influenza A Virus, H2N2 Subtype
Influenza, Human
Mutation
Phenotype
Polymorphism, Single-Stranded Conformational
Recombination, Genetic
Viral Nonstructural Proteins

Source

Open in PubMed

Identifiers

PMID: 17872525
DOI: 10.1099/vir.0.83014-0

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