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Genetic bases of the temperature-sensitive phenotype of a master donor virus used in live attenuated influenza vaccines: A/Leningrad/134/17/57 (H2N2).

Virology - 10 Apr 2011

Isakova-Sivak Irina, Chen Li-Mei, Matsuoka Yumiko, Voeten J Theo M, Kiseleva Irina, Heldens Jacco G M, den Bosch Han van, Klimov Alexander, Rudenko Larisa, Cox Nancy J, Donis Ruben O

Abstract excerpt

Trivalent live attenuated influenza vaccines whose type A components are based on cold-adapted A/Leningrad/134/17/57 (H2N2) (caLen17) master donor virus (MDV) have been successfully used in Russia for decades to control influenza. The vaccine virus comprises hemagglutinin and neuraminidase genes from the circulating viruses and the remaining six genes from the MDV. The latter confer temperature-sensitive (ts) and...

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PMID: 21315402
DOI: 10.1016/j.virol.2011.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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