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Article

Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly.

Cell - 20 Sept 1996

Chen P, Hochstrasser M

Abstract excerpt

The eukaryotic 20S proteasome is responsible for the degradation of many cellular proteins, but how it is assembled and how its distinct active sites are formed are not understood. Like other proteasome subunits, the yeast Doa3 protein is synthesized in precursor form. We show that the N-terminal propeptide is required for Doa3 incorporation into the proteasome and, remarkably, that the propeptide functions in...

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PMID: 8808631
DOI: 10.1016/s0092-8674(00)80171-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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