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Article

Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.

The Journal of biological chemistry - 10 Nov 1995

Roy K, Mitsugi K, Sirlin S, Shane B, Sirotnak F M

Abstract excerpt

L1210 cell variants selected in the presence of the lipophilic dihydrofolate reductase inhibitor, metoprine, expressed increased levels of one-carbon, reduced folate transport inward (Sirotnak, F. M., Moccio, D. M., and Yang, C.-H. (1984) J. Biol. Chem. 259, 13139-13144). Growth of one of these variants (L1210/R69), with metoprine in the presence of decreasing concentrations of 1,L5-CHO-folateH4 (natural...

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PMID: 7592937
DOI: 10.1074/jbc.270.45.26918

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