Article
Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
The Journal of biological chemistry - 10 Nov 1995
Roy K, Mitsugi K, Sirlin S, Shane B, Sirotnak F M
Abstract excerpt
L1210 cell variants selected in the presence of the lipophilic dihydrofolate reductase inhibitor, metoprine, expressed increased levels of one-carbon, reduced folate transport inward (Sirotnak, F. M., Moccio, D. M., and Yang, C.-H. (1984) J. Biol. Chem. 259, 13139-13144). Growth of one of these v...
Topics
- Amino Acid Sequence
- Animals
- Drug Resistance
- Folic Acid Antagonists
- Gene Amplification
- Gene Expression
- Genetic Variation
- Humans
- Leukemia L1210
- Mice
- Molecular Sequence Data
- Peptide Synthases
- Pyrimethamine
- RNA, Messenger
- Transcription, Genetic
- Tumor Cells, Cultured