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Article

Heterogeneity of hepatitis B virus C-gene sequences: implications for amplification and sequencing.

Journal of hepatology - 1 Apr 1993

Miska S, Günther S, Vassilev M, Meisel H, Pape G, Will H

Abstract excerpt

Occasionally direct sequencing of amplified hepatitis B virus DNA leads to weak signals on autoradiograms. Using amplified C-gene sequences we investigated whether this is due to sequence heterogeneity of virus populations and use of inappropriate primers for direct sequencing. High C-gene sequence heterogeneity (point mutations, stop codons and a one codon deletion) was observed in HBV genomes from serum of a...

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Identifiers

PMID: 8340610
DOI: 10.1016/s0168-8278(05)80009-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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