Article
Sensitive method for identification of minor hepatitis B mutant viruses.
Virology - 1 Mar 1992
Grötzinger T, Will H
Abstract excerpt
There is increasing evidence for selection of hepatitis B virus (HBV) mutants during the natural course of infection, after immunization, and during interferon therapy. These mutants can prolong viral persistence, escape immune-mediated elimination, and influence the clinical sequelae of infection. Here we describe a sensitive and reliable method that allows detection of HBV mutants within a heterogeneous virus...
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