Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity within the nonstructural protein 5-encoding region of hepatitis C viruses from a single patient.

Gene - 15 Aug 1992

Murakawa K, Esumi M, Kato T, Kambara H, Shikata T

Abstract excerpt

Nucleotide (nt) sequence heterogeneity of the hepatitis C virus (HCV) genome derived from a single carrier was investigated. A polymerase chain reaction (PCR) product of 311 bp in the putative nonstructural protein 5-encoding region was directly sequenced, while part of a PCR product was cloned, and sequence analyses were carried out for 27 independent clones. Although 14 of the 27 clones were conserved, ten...

Topics

Base Sequence
Cloning, Molecular
Genome, Viral
Hepacivirus
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Homology, Nucleic Acid
Viral Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1322345
DOI: 10.1016/0378-1119(92)90733-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1322345-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity within the nonstructural protein 5-encoding region of hepatitis C viruses from a single patient.PMID 1322345Read ↗

Comparative sequence analysis of the core- and NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue.Semantic proximity Read ↗

Sequence analysis of the 5' noncoding region of hepatitis C virus.Semantic proximity Read ↗

Sequence heterogeneity within three different regions of the hepatitis G virus genome.Semantic proximity Read ↗

Genetic variability and characterization of non-structural region 5 of hepatitis C virus genome from Chinese patients.Semantic proximity Read ↗

Degree and distribution of variability in the 5' untranslated, E1, E2/NS1 and NS5 regions of the hepatitis C virus (HCV).Semantic proximity Read ↗

Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution.Semantic proximity Read ↗

Sequence variability of the 5' UTR in isolates of hepatitis C virus in China.Semantic proximity Read ↗

Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals.Semantic proximity Read ↗

Genetic heterogeneity of the hepatitis C virus.Semantic proximity Read ↗

Genetic heterogeneity of the NS3 protease gene in hepatitis C virus genotype 1 from untreated infected patients.Semantic proximity Read ↗

Sequence diversity of hepatitis C viral genomes.Semantic proximity Read ↗

Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.