Article
Heterogeneity within the nonstructural protein 5-encoding region of hepatitis C viruses from a single patient.
Gene - 15 Aug 1992
Murakawa K, Esumi M, Kato T, Kambara H, Shikata T
Abstract excerpt
Nucleotide (nt) sequence heterogeneity of the hepatitis C virus (HCV) genome derived from a single carrier was investigated. A polymerase chain reaction (PCR) product of 311 bp in the putative nonstructural protein 5-encoding region was directly sequenced, while part of a PCR product was cloned, and sequence analyses were carried out for 27 independent clones. Although 14 of the 27 clones were conserved, ten...
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