Article
Deoxycytidine methylation and the origin of spontaneous transition mutations in mammalian cells.
Somatic cell and molecular genetics - 1 May 1993
Tasheva E S, Roufa D J
Abstract excerpt
Previously we described a recurrent, site-specific G4784 --> A transition mutation affecting exon V of the Chinese hamster ovary cell RPS14 gene. Because the mutation is located within a CpG dinucleotide, we considered the possibility that deoxycytidine methylation might be responsible for the tr...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA Mutational Analysis
- DNA, Single-Stranded
- Deoxycytidine
- Exons
- Methylation
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction