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Article

Induced reversion of a spontaneous point mutation within the Chinese hamster HPRT gene to the wild-type sequence.

Mutagenesis - 1 Nov 1990

Rossiter B J, Muzny D M, Hampson I, Caskey C T, Fox M

Abstract excerpt

The Chinese hamster hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient cell line TG15 produces apparently normal HPRT mRNA by northern analysis and was therefore presumed to contain a point mutation within the coding region. Sequencing cDNA from the TG15 cell line revealed an A to G transition which results in the substitution of the amino acid glycine for aspartic acid at position 135. TG15 cells...

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PMID: 1702179
DOI: 10.1093/mutage/5.6.605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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