Article
Linked spontaneous CG----TA mutations at CpG sites in the gene for protein kinase regulatory subunit.
Molecular and cellular biology - 1 Feb 1992
Steinberg R A, Gorman K B
Abstract excerpt
CG----TA transitions at CpG sequences account for many human point mutations and are thought to result from hydrolytic deamination of 5-methylcytosine residues in these sites. The gene for regulatory subunit of murine cyclic AMP-dependent protein kinase has two closely linked CpG sites, one of wh...
Topics
- Animals
- Arginine
- Base Sequence
- Cloning, Molecular
- Codon
- Cyclic AMP
- Dinucleoside Phosphates
- Electrophoresis, Gel, Two-Dimensional
- Kinetics
- Mice
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Tumor Cells, Cultured