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Article

Linked spontaneous CG----TA mutations at CpG sites in the gene for protein kinase regulatory subunit.

Molecular and cellular biology - 1 Feb 1992

Steinberg R A, Gorman K B

Abstract excerpt

CG----TA transitions at CpG sequences account for many human point mutations and are thought to result from hydrolytic deamination of 5-methylcytosine residues in these sites. The gene for regulatory subunit of murine cyclic AMP-dependent protein kinase has two closely linked CpG sites, one of which is a strong hotspot for spontaneous CG----TA mutations leading to cyclic AMP resistance in S49 mouse lymphoma...

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Identifiers

PMID: 1310152
DOI: 10.1128/mcb.12.2.767-772.1992
PMCID: PMC364294

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