Article
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1993
Silver D P, Spanopoulou E, Mulligan R C, Baltimore D
Abstract excerpt
As a probe of whether RAG-1 and RAG-2 gene products activate other genes or form part of the recombinase itself, certain mutants of the RAG genes were assayed for their ability to activate variable-diversity-joining region [V(D)J] recombination in a plasmid substrate in fibroblasts. The results i...
Topics
- 3T3 Cells
- Animals
- Cell Line
- DNA-Binding Proteins
- Genes, Immunoglobulin
- Genes, RAG-1
- Homeodomain Proteins
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Mice
- Mutation
- Plasmids
- Proteins
- Recombination, Genetic
- Retroviridae
- Structure-Activity Relationship