Article
How to make ends meet in V(D)J recombination.
Current opinion in immunology - 1 Apr 2001
Grawunder U, Harfst E
Abstract excerpt
In most vertebrate species analyzed so far, the diversity of soluble or membrane-bound antigen-receptors expressed by B and T lymphocytes is generated by V(D)J recombination. During this process, the coding regions for the variable domains of antigen-receptors are created by the joining of subexons that are randomly selected from arrays of tandemly repeated V, D (sometimes) and J gene segments. This involves the...
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