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Article

RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination

1 Oct 2021

Abstract excerpt

RAG1 and RAG2 form a tetramer nuclease to initiate V(D)J recombination in developing T and B lymphocytes. The RAG1 protein evolves from a transposon ancestor and possesses nuclease activity that requires interaction with RAG2. Here, we show that the human RAG1 aggregates in the nucleus in the absence of RAG2, exhibiting an extremely low V(D)J recombination activity. In contrast, RAG2 does not aggregate by itself,...

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Identifiers

PMID: 34644584
DOI: 10.1016/j.celrep.2021.109824

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