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Article

RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.

Nucleic acids research - 1 Oct 2008

Curry John D, Schlissel Mark S

Abstract excerpt

Variable (diversity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J portions recombining first and then an upstream V joins that recombinant. We present evidence that the non-core domain of recombination activating gene (RAG) protein 2 is involved in the regulation of recombinatorial order. In mice lacking the non-core domain of RAG2 the ordered rearrangement is...

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Share to Cell Cycle
Share to Gene Rearrangement, B-Lymphocyte
Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

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Share to Gene Rearrangement, delta-Chain T-Cell Antigen Receptor

Share to Gene Rearrangement, T-Lymphocyte

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Source

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Identifiers

PMID: 18776220
DOI: 10.1093/nar/gkn553
PMCID: PMC2566892

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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