RAG and RAG defects.

Abstract excerpt

Products of the recombination-activating gene (RAG) play a crucial role in lymphoid cell development. During the past year, the functional properties of RAG protein domains have been better defined. Some mutations that alter the amino acid sequence of RAG1 or RAG2 have been shown to disturb B cell generation and to partially disturb T cell generation, resulting in Omenn syndrome in humans; moreover, peripheral...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA-Binding Proteins
• Share to RAG2 gene
• Share to Homeodomain Proteins