The effects of transfected mutant and wild type RAG genes in different cell types.

Abstract excerpt

The ability to perform V(D)J recombination can be transferred to non-lymphoid cells by stable or transient transfection of the RAG genes. This fact was used to test the effect of wild type and mutant RAG-genes on the V(D)J recombination activity in recombination competent and incompetent cells. Cotransfection of wild type RAG genes induced V(D)J recombination in NIH 3T3 fibroblasts, but had no effect in the pre B...

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