Article
Expression and V(D)J recombination activity of mutated RAG-1 proteins.
Nucleic acids research - 11 Dec 1993
Sadofsky M J, Hesse J E, McBlane J F, Gellert M
Abstract excerpt
The products of the RAG-1 and RAG-2 genes are essential for the recombination of the DNA encoding the antigen receptors of the developing immune system. Little is known of the specific role these genes play. We have explored the sequences encoding mouse RAG-1 by deleting large parts of the gene a...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Cell Line, Transformed
- Cell Nucleus
- DNA
- DNA Topoisomerases, Type I
- Gene Rearrangement, B-Lymphocyte
- Genes, RAG-1
- Homeodomain Proteins
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Precipitin Tests
- Proteins