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Article

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

Genes & development - 1 Sept 1995

Sadofsky M J, Hesse J E, van Gent D C, Gellert M

Abstract excerpt

The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant o...

Topics

Base Sequence
Genes, RAG-1
Homeodomain Proteins
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Plasmids
Proteins
Receptors, Antigen, T-Cell
Recombination, Genetic
Sequence Deletion
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7657170
DOI: 10.1101/gad.9.17.2193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7657170-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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