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Article

Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.

Molecular and cellular biology - 1 Jul 1993

Vassbotn F S, Andersson M, Westermark B, Heldin C H, Ostman A

Abstract excerpt

A non-receptor-binding mutant of the platelet-derived growth factor (PDGF) A chain, PDGF-0, was generated by exchanging 7 amino acids in the sequence. The mutant chains formed dimers that were similar to wild-type PDGF-AA with regard to stability and rate of processing to the mature 30-kDa secreted forms. Moreover, the mutant chains formed disulfide-bonded heterodimers with the PDGF B chain in NIH 3T3 cells...

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Identifiers

PMID: 8321214
DOI: 10.1128/mcb.13.7.4066-4076.1993
PMCID: PMC359956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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