Article
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.
Molecular and cellular biology - 1 Dec 1993
Shamah S M, Stiles C D, Guha A
Abstract excerpt
Malignant astrocytoma is the most common primary human brain tumor. Most astrocytomas express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could close an autocrine loop. It is not known whether these autocrine loops contribute to the transformed phenotype of astr...
Topics
- 3T3 Cells
- Animals
- Astrocytoma
- Cell Adhesion
- Cell Division
- Cell Transformation, Neoplastic
- DNA, Complementary
- Genes, Dominant
- Humans
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Phenotype
- Platelet-Derived Growth Factor
- Transformation, Genetic
- Transplantation, Heterologous
- Tumor Cells, Cultured