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Article

Platelet-derived growth factor AB heterodimer interchain interactions influence secretion as well as receptor binding and activation.

Biochemistry - 2 Nov 1993

May M, Aaronson S A, LaRochelle W J

Abstract excerpt

Platelet-derived growth factor (PDGF) is a disulfide-linked dimer comprised of two related polypeptide chains. To investigate the effects of an inactivating lesion introduced into one chain of the nascent PDGF dimer, approaches were developed to optimize synthesis, assembly, secretion, and purification of heterodimers between normal PDGF A and wild-type or mutant PDGF B. PDGF AB heterodimers were released into...

Topics

3T3 Cells
Animals
Biopolymers
Cell Line
Humans
Mice
Mitosis
Mutation
Platelet-Derived Growth Factor
Protein Processing, Post-Translational
Receptors, Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Source

Identifiers

PMID: 8218243
DOI: 10.1021/bi00094a033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8218243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Platelet-derived growth factor AB heterodimer interchain interactions influence secretion as well as receptor binding and activation.PMID 8218243Read ↗

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