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Article

Combined anti-PDGFRalpha and PDGFRbeta targeting in non-small cell lung cancer.

International journal of cancer - 1 Apr 2009

Reinmuth Niels, Liersch Ruediger, Raedel Miriam, Fehrmann Frauke, Fehrmann Nicole, Bayer Michael, Schwoeppe Christian, Kessler Torsten, Berdel Wolfgang, Thomas Michael, Mesters Rolf M

Abstract excerpt

Activation of the platelet-derived growth factor (PDGF)-receptors is critically involved into various stromal cell functions including recruitment of stromal cells and vascular endothelial growth factor (VEGF) induction in tumor and perivascular cells. To evaluate the effects of combined PDGFRalpha and -beta inhibition in a non-small cell lung cancer model, we stably transfected A549 lung cancer cells with the...

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Identifiers

PMID: 19115205
DOI: 10.1002/ijc.24109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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