Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined anti-PDGFRalpha and PDGFRbeta targeting in non-small cell lung cancer.

International journal of cancer - 1 Apr 2009

Reinmuth Niels, Liersch Ruediger, Raedel Miriam, Fehrmann Frauke, Fehrmann Nicole, Bayer Michael, Schwoeppe Christian, Kessler Torsten, Berdel Wolfgang, Thomas Michael, Mesters Rolf M

Abstract excerpt

Activation of the platelet-derived growth factor (PDGF)-receptors is critically involved into various stromal cell functions including recruitment of stromal cells and vascular endothelial growth factor (VEGF) induction in tumor and perivascular cells. To evaluate the effects of combined PDGFRalp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Delivery Systems
Share to Extracellular Matrix
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Pathologic

Share to Platelet-Derived Growth Factor

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptor, Platelet-Derived Growth Factor beta

Share to Stromal Cells

Source

Identifiers

PMID: 19115205
DOI: 10.1002/ijc.24109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19115205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined anti-PDGFRalpha and PDGFRbeta targeting in non-small cell lung cancer.PMID 19115205Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.Semantic proximity Read ↗

Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism.Semantic proximity Read ↗

PDGF receptors as targets in tumor treatment.Semantic proximity Read ↗

Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.Semantic proximity Read ↗

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.Semantic proximity Read ↗

GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivoSemantic proximity Read ↗

Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.Semantic proximity Read ↗

Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.Semantic proximity Read ↗

Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.Semantic proximity Read ↗

PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.Semantic proximity Read ↗

CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM-1 and Fas expression and proliferation of human non-small cell lung tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.