Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.

The Journal of biological chemistry - 6 Sept 2002

Wilcox Lisa J, Balderes Dina A, Wharton Brook, Tinkelenberg Arthur H, Rao Govinda, Sturley Stephen L

Abstract excerpt

In contrast to lipoprotein-mediated sterol uptake, free sterol influx by eukaryotic cells is poorly understood. To identify components of non-lipoprotein-mediated sterol uptake, we utilized strains of Saccharomyces cerevisiae that accumulate exogenous sterol due to a neomorphic mutation in the transcription factor, UPC2. Two congenic upc2-1 strains, differing quantitatively in aerobic sterol uptake due to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Northern

Share to Open Reading Frames

Share to Sodium Azide

Share to Sterols

Share to Vanadates

Source

Identifiers

PMID: 12077145
DOI: 10.1074/jbc.M204707200

Genes

HAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.PMID 12077145Read ↗

A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism.Semantic proximity Read ↗

Mutations in the nucleotide-binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast.Semantic proximity Read ↗

In yeast, upc2-1 confers a decrease in tolerance to LiCl and NaCl, which can be suppressed by the P-type ATPase encoded by ENA2.Semantic proximity Read ↗

Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways.Semantic proximity Read ↗

Candida glabrata maintains two HAP1 ohnologs, HAP1A and HAP1B , for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditionsSemantic proximity Read ↗

Transcriptome profiling of a Saccharomyces cerevisiae mutant with a constitutively activated Ras/cAMP pathway.Semantic proximity Read ↗

Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in <i>Candida glabrata</i>Semantic proximity Read ↗

Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.Semantic proximity Read ↗

A microarray-assisted screen for potential Hap1 and Rox1 target genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.