Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae.

Environmental and molecular mutagenesis - 1 Jan 2000

Peterson C, Kordich J, Milligan L, Bodor E, Siner A, Nagy K, Paquin C E

Abstract excerpt

We report here the use of the ADH4:CUP1 amplification detection system to identify five high amplification rate (HAR) strains of Saccharomyces cerevisiae that display 40- to 600-fold higher amplification rates than those of parental strains. We have identified a mutation in RAD3 DNA repair helicase gene in HAR strain B9-40 that results in a 40-fold increase in amplification rate. RAD3 is the functional homolog of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Methyl Methanesulfonate

Share to MutS Homolog 2 Protein

Share to Rad52 DNA Repair and Recombination Protein

Share to Radiation Tolerance

Share to Ultraviolet Rays

Source

Identifiers

PMID: 11152565
DOI: 10.1002/1098-2280(2000)36:4<325::aid-em8>3.0.co;2-b

Genes

RAD52
MSH2
ADH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae.PMID 11152565Read ↗

Phenotypic identification of amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.Semantic proximity Read ↗

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.Semantic proximity Read ↗

Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer.Semantic proximity Read ↗

Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans.Semantic proximity Read ↗

A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae.Semantic proximity Read ↗

Multiple recombination pathways for sister chromatid exchange in Saccharomyces cerevisiae: role of RAD1 and the RAD52 epistasis group genes.Semantic proximity Read ↗

Error-free RAD52 pathway and error-prone REV3 pathway determines spontaneous mutagenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation.Semantic proximity Read ↗

Spontaneous and double-strand break-induced recombination, and gene conversion tract lengths, are differentially affected by overexpression of wild-type or ATPase-defective yeast Rad54.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.