Overexpression of yeast PAM1 gene permits survival without protein phosphatase 2A and induces a filamentous phenotype.

Abstract excerpt

Protein phosphatase 2A (PP2A) is an essential enzyme which is present in all eukaryotic cells. PP2A has been implicated in regulating various metabolic processes and also in the control of cell cycle progression. In the yeast Saccharomyces cerevisiae, the catalytic subunit of PP2A is encoded by two duplicated genes, PPH21 and PPH22. A third related gene, PPH3, also contributes some PP2A activity. We have used a...

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