Article
The effect of misspecifying allele frequencies in incompletely typed families.
Genetic epidemiology - 1 Jan 1993
Knapp M, Seuchter S A, Baur M P
Abstract excerpt
To examine the effect of a misspecified marker allele frequency, the segregation of a marker unlinked to Alzheimer's disease was simulated for the typed members of the GAW8-FAD4 pedigree. Lod scores were calculated for different assumed marker allele frequencies. The results show that a misspecification of marker frequency can lead to spuriously high lod scores. The affecteds-only method for linkage analysis is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.