Article
The impact of some parameters on linkage analysis of Alzheimer's disease.
Genetic epidemiology - 1 Jan 1993
Xu J F, Taylor E W, Lung F W, Chung A S, Chase G A, Maestri N E, Meyers D A
Abstract excerpt
The two-point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age-dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage.
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