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Article

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.

The EMBO journal - 1 Feb 1994

Stewart E, Kobayashi H, Harrison D, Hunt T

Abstract excerpt

The specific and rapid destruction of cyclins A and B during mitosis is their most remarkable property. A short peptide motif of approximately 10 amino acids near the N-terminus, known as the destruction box, is absolutely required for programmed proteolysis. In this paper we show that although the destruction box is necessary for the degradation of cyclin A, it is not sufficient. Mutant versions of cyclin A that...

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Identifiers

PMID: 8313903
DOI: 10.1002/j.1460-2075.1994.tb06296.x
PMCID: PMC394847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.PMID 8313903Read ↗

Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.Semantic proximity Read ↗

The roles of Drosophila cyclins A and B in mitotic control.Semantic proximity Read ↗

DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae.Semantic proximity Read ↗

The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23.Semantic proximity Read ↗

Cyclin A-Cys41 does not undergo cell cycle-dependent degradation in Xenopus extracts.Semantic proximity Read ↗

Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B.Semantic proximity Read ↗

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.Semantic proximity Read ↗

Characterization and Expression of Mammalian Cyclin B3, a Prepachytene Meiotic CyclinSemantic proximity Read ↗

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts.Semantic proximity Read ↗

Destruction with a box: substrate recognition by the anaphase-promoting complex.Semantic proximity Read ↗

A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis.Semantic proximity Read ↗

Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.Semantic proximity Read ↗

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