Article
DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae.
Journal of cell science - 1 Aug 1997
Germain D, Hendley J, Futcher B
Abstract excerpt
Cell cycle progression is mediated by waves of specific cyclin dependent kinases (CDKs) in all eukaryotes. Cyclins are degraded by the ubiquitin pathway of proteolysis. The recent identification of several components of the cyclin proteolysis machinery has highlighted both the importance of proteolysis at multiple transition points in the cell cycle and the involvement of other substrates degraded by the same...
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