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Article

The roles of Drosophila cyclins A and B in mitotic control.

Cell - 4 May 1990

Lehner C F, O'Farrell P H

Abstract excerpt

We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed...

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Identifiers

PMID: 2139805
DOI: 10.1016/0092-8674(90)90535-m
PMCID: PMC2753431

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