Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23.

Archives of biochemistry and biophysics - 15 Nov 2002

Meyn Malcolm A, Melloy Patricia G, Li Jie, Holloway Sandra L

Abstract excerpt

Properly regulated cyclin proteolysis is critical for normal cell cycle progression. A nine-amino acid peptide motif called the destruction box (D box) is present at the N terminus of the yeast mitotic cyclins. This short sequence is required for cyclin ubiquitination and subsequent proteolysis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Anaphase-Promoting Complex-Cyclosome
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin B

Share to Ligases

Share to Protein Subunits

Share to Two-Hybrid System Techniques

Share to Ubiquitin-Protein Ligase Complexes

Source

Identifiers

PMID: 12413490
DOI: 10.1016/s0003-9861(02)00467-8

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12413490-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23.PMID 12413490Read ↗

Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets.Semantic proximity Read ↗

DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae.Semantic proximity Read ↗

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins.Semantic proximity Read ↗

Identification of a cullin homology region in a subunit of the anaphase-promoting complex.Semantic proximity Read ↗

G2 cyclins are required for the degradation of G1 cyclins in yeast.Semantic proximity Read ↗

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Semantic proximity Read ↗

Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.Semantic proximity Read ↗

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation.Semantic proximity Read ↗

A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis.Semantic proximity Read ↗

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.