Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Destruction with a box: substrate recognition by the anaphase-promoting complex.

Molecular cell - 16 Jan 2004

Zachariae Wolfgang

Abstract excerpt

Destruction boxes mark cyclin B and other proteins degraded in mitosis for ubiquitination by the anaphase-promoting complex (APC/C). In a paper in this issue of Molecular Cell, Yamano et al. show that destruction boxes directly bind to the APC/C in a cell cycle-regulated manner. Interestingly, this interaction does not require APC/C activators of the Cdc20 family, which were thought to be essential for recruiting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins
Share to Cyclin B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligases

Share to Mitosis

Share to Mutation

Share to Ubiquitin

Share to Xenopus

Source

Identifiers

PMID: 14731388
DOI: 10.1016/s1097-2765(03)00530-6

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Destruction with a box: substrate recognition by the anaphase-promoting complex.PMID 14731388Read ↗

How APC/C-Cdc20 changes its substrate specificity in mitosis.Semantic proximity Read ↗

Regulated degradation of spindle assembly factors by the anaphase-promoting complex.Semantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.Semantic proximity Read ↗

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.Semantic proximity Read ↗

Mitotic activation of the kinase Aurora-A requires its binding partner Bora.Semantic proximity Read ↗

The D box asserts itself.Semantic proximity Read ↗

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.Semantic proximity Read ↗

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Semantic proximity Read ↗

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.