Article
Assessment of clinical parameters associated with increased frequency of mutant T cells in patients with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Feb 1994
Dawisha S M, Gmelig-Meyling F, Steinberg A D
Abstract excerpt
OBJECTIVE: To determine the clinical features that contribute to an increased frequency of mutant T cells (FMC) in patients with systemic lupus erythematosus (SLE). METHODS: During in vivo T cell division, there are errors in replication which give rise to mutations throughout the genome. An estimate of such mutations may be obtained by focusing on mutations in the hprt gene, which can be screened by assessing...
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